Tg(Myh6-SOD2,Tyr)3Pne
Transgene Detail

Summary

• Symbol: Tg(Myh6-SOD2,Tyr)3Pne
• Name: transgene insertion 3, Paul N Epstein
• MGI ID: MGI:4360100
• Synonyms: MnSOD3, MS, MySOD
• Transgene: Tg(Myh6-SOD2,Tyr)3Pne Location: unknown
• Alliance: Tg(Myh6-SOD2,Tyr)3Pne page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-SOD2,Tyr)3Pne expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD2 (6648)

  Sod2	(MGI:98352)

• Mutation details: A transgenic construct containing the human, superoxide dismutase 2, mitochondrial gene under the control of the mouse myosin, heavy polypeptide 6, cardiac muscle, alpha, promoter and a polyadenylation sequence (550-bp fragment of the rat insulin II gene) was co-injected with a tyrosinase minigene where tyrosinase is under the control of the tyrosinase promoter, commonly referred to as TyBs into fertilized FVB mouse eggs. Founder line 3 was subsequently established. (J:106815, J:152215)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:106815 Mantena SK, et al., Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors. J Nutr. 2005 Dec;135(12):2871-7
• All: 5 reference(s)