Dlx6os1^tm1.1Jhdk
Targeted Allele Detail

Summary

• Symbol: Dlx6os1^tm1.1Jhdk
• Name: distal-less homeobox 6, opposite strand 1; targeted mutation 1.1, Jhumku D Kohtz
• MGI ID: MGI:4360101
• Synonyms: Evf2^TS
• Gene: Dlx6os1 Location: Chr6:6820543-6871627 bp, - strand Genetic Position: Chr6, 2.68 cM
• Alliance: Dlx6os1^tm1.1Jhdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152532
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: A STOP cassette (triple polyadenylation signal sequences) was inserted into exon 1, truncating Dlx6os1 splice variant Evf2 from 3.7 kb to 101 bp without affecting the transcription of splice variant Evf1. RT-PCR confirmed that the expression of Dlx5 and Dlx6 are increased. A loxP site flanked neomycin resistance gene cassette was removed by cre-mediated recombination. (J:152532)

Expression

In Mice Carrying this Mutation:	86 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dlx6os1 Mutation: 3 strains or lines available

References

• Original: J:152532 Bond AM, et al., Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry. Nat Neurosci. 2009 Aug;12(8):1020-7
• All: 5 reference(s)