Ehd4^tm1.1Haba
Targeted Allele Detail

Summary

• Symbol: Ehd4^tm1.1Haba
• Name: EH-domain containing 4; targeted mutation 1.1, Hamid Band
• MGI ID: MGI:4360181
• Synonyms: Ehd4^-
• Gene: Ehd4 Location: Chr2:119919958-119985028 bp, - strand Genetic Position: Chr2, 60.16 cM
• Alliance: Ehd4^tm1.1Haba page

Reduced testicular size in Ehd4^tm1.1Haba/Ehd4^tm1.1Haba mice

Show the 8 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152735
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Using a series of recombineering reactions, two loxP sites flanking exon 1 were introduced. An FRT-Neo-FRT selection cassette was immediately preceding the second loxP site. Exon 1 and the Neo cassette were deleted upon Cre-mediated recombination. No protein was detected in the lung, kidney, heart, spleen, brain, liver, thymus, or testis of homozygous mice by Western blot. (J:160188)

Generation of the Ehd4^tm1.1Haba allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ehd4 Mutation: 26 strains or lines available

Notes

ES cell line = B6T (C57BL/6)

References

• Original: J:152735 Sengupta S, et al., EHD4 and CDH23 are interacting partners in cochlear hair cells. J Biol Chem. 2009 Jul 24;284(30):20121-9
• All: 4 reference(s)