Atp1b1^tm1.1Akra
Targeted Allele Detail

Summary

• Symbol: Atp1b1^tm1.1Akra
• Name: ATPase, Na+/K+ transporting, beta 1 polypeptide; targeted mutation 1.1, Ayyappan K Rajasekaran
• MGI ID: MGI:4360184
• Gene: Atp1b1 Location: Chr1:164264678-164285924 bp, - strand Genetic Position: Chr1, 71.75 cM
• Alliance: Atp1b1^tm1.1Akra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152596
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 2. Transient cre expression in ES cells removed exon 2. (J:152596)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp1b1 Mutation: 20 strains or lines available

References

• Original: J:152596 Barwe SP, et al., Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit. J Mol Cell Cardiol. 2009 Oct;47(4):552-60
• All: 1 reference(s)