Inpp5e^tm1.2Ssch
Targeted Allele Detail

Summary

• Symbol: Inpp5e^tm1.2Ssch
• Name: inositol polyphosphate-5-phosphatase E; targeted mutation 1.2, Stephane Schurmans
• MGI ID: MGI:4360187
• Synonyms: Inpp5e^delta
• Gene: Inpp5e Location: Chr2:26286261-26299215 bp, - strand Genetic Position: Chr2, 18.88 cM, cytoband A3
• Alliance: Inpp5e^tm1.2Ssch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152712
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 6 and a second loxP site and an frt flanked neo cassette were inserted into intron 8 via homologous recombination. Cre mediated recombination removed exons 7 and 8. (J:152712)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inpp5e Mutation: 29 strains or lines available

References

• Original: J:152712 Jacoby M, et al., INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nat Genet. 2009 Sep;41(9):1027-31
• All: 9 reference(s)