Tg(Camk2a-HRAS*G12V)1Sva
Transgene Detail

Summary

• Symbol: Tg(Camk2a-HRAS*G12V)1Sva
• Name: transgene insertion 1, Alcino Silva
• MGI ID: MGI:4360216
• Synonyms: H-ras^G12V, Tg(Camk2a-HRAS1*G12V)1Sva
• Transgene: Tg(Camk2a-HRAS*G12V)1Sva Location: unknown
• Alliance: Tg(Camk2a-HRAS*G12V)1Sva page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The promoter was used to drive expression in postmitotic neurons of the HA-tagged human cDNA that contains nucleotide substitutions that result in the amino acid substitution of valine for glycine at position 12 (G12V). This mutation produces a constitutively active product. (J:102160)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:102160 Kushner SA, et al., Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway. J Neurosci. 2005 Oct 19;25(42):9721-34
• All: 2 reference(s)