Tg(Myh6-CREB1*S133A)1Jml
Transgene Detail

Summary

• Symbol: Tg(Myh6-CREB1*S133A)1Jml
• Name: transgene insertion 1, Jeffrey M Leiden
• MGI ID: MGI:4360273
• Synonyms: CREB^A133
• Transgene: Tg(Myh6-CREB1*S133A)1Jml Location: unknown
• Alliance: Tg(Myh6-CREB1*S133A)1Jml page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-CREB1*S133A)1Jml expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CREB1 (1385)

  Creb1

  (MGI:88494)

  Transgene codes for a protein with a serine to alanine mutation.

• Mutation details: The human open reading frame with nucleotide substitutions that result in the amino acid substitution of alanine for serine at position 133 was inserted into a vector containing the promoter and untranslated exons 1 through 3 of the murine promoter followed by an SV40 polyadenylation sequence. Transgene promoter drives expression in cardiac myocytes. Three founder lines were established (lines 1, 2, and 3) with between 15 and 50 cpoies of the transgene, respectively. (J:133881)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:133881 Fentzke RC, et al., Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart. J Clin Invest. 1998 Jun 1;101(11):2415-26
• All: 8 reference(s)