Pak4^tm2.2Amin
Targeted Allele Detail

Summary

• Symbol: Pak4^tm2.2Amin
• Name: p21 (RAC1) activated kinase 4; targeted mutation 2.2, Audrey Minden
• MGI ID: MGI:4360338
• Synonyms: Pak4^delta
• Gene: Pak4 Location: Chr7:28258244-28297609 bp, - strand Genetic Position: Chr7, 16.84 cM
• Alliance: Pak4^tm2.2Amin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152821
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removed exons 2 through 4 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embyonic fibroblast extracts. (J:152821)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pak4 Mutation: 94 strains or lines available

References

• Original: J:152821 Tian Y, et al., Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mech Dev. 2009 Aug-Sep;126(8-9):710-20
• All: 2 reference(s)