Erbb3^tm2.1Dwt
Targeted Allele Detail

Summary

• Symbol: Erbb3^tm2.1Dwt
• Name: erb-b2 receptor tyrosine kinase 3; targeted mutation 2.1, David Threadgill
• MGI ID: MGI:4360355
• Synonyms: Erbb3^f, Erbb3^tm1Dwt2
• Gene: Erbb3 Location: Chr10:128403392-128425504 bp, - strand Genetic Position: Chr10, 77.1 cM
• Alliance: Erbb3^tm2.1Dwt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152703
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A lox71 site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 2. Transient cre expression in ES cells removes the neo cassette leaving exon 2 floxed. (J:152703)

Generation of the Erbb3^tm2.1Dwt allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb3 Mutation: 48 strains or lines available

References

• Original: J:152703 Lee D, et al., Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. J Clin Invest. 2009 Sep;119(9):2702-13
• All: 7 reference(s)