Grik4^tm1(cre)Ksak
Targeted Allele Detail

Summary

• Symbol: Grik4^tm1(cre)Ksak
• Name: glutamate receptor, ionotropic, kainate 4; targeted mutation 1, Kenji Sakimura
• MGI ID: MGI:4360478
• Synonyms: Grik4-Cre, telencephalin-Cre
• Gene: Grik4 Location: Chr9:42431708-42856296 bp, - strand Genetic Position: Chr9, 23.8 cM
• Alliance: Grik4^tm1(cre)Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152455
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Grik4^tm1(cre)Ksak expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Grik4 (MGI:95817)

• Mutation details: Cre was inserted 3' to the translational start site and replaced the remainder of the first coding exon. Cre-driven expression is primarily in CA3 pyramidal cells of the hippocampus. (J:152455)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Grik4 (mouse) Summary of all recombinase alleles driven by Grik4. Comparative matrix view of recombinase activities Alliance mouse Grik4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grik4 Mutation: 48 strains or lines available

References

• Original: J:152455 Akashi K, et al., NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J Neurosci. 2009 Sep 2;29(35):10869-82
• All: 5 reference(s)