Atf4^tm1Kry
Targeted Allele Detail

Summary

• Symbol: Atf4^tm1Kry
• Name: activating transcription factor 4; targeted mutation 1, Gerard Karsenty
• MGI ID: MGI:4360484
• Synonyms: Atf4^fl
• Gene: Atf4 Location: Chr15:80139385-80141742 bp, + strand Genetic Position: Chr15, 37.85 cM
• Alliance: Atf4^tm1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152695
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 2 and a loxP site was inserted downstream of exon 3. However, further sequencing analysis revealed that the insertion of the loxp cassette disrupted the first splice site and resulted in an allele that, in contrast to the wildtype allele, did not result in expression of encoded protein. (J:152695, J:253375)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf4 Mutation: 22 strains or lines available

References

• Original: J:152695 Yoshizawa T, et al., The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest. 2009 Sep;119(9):2807-17
• All: 8 reference(s)