Sostdc1^tm2Myan
Targeted Allele Detail

Summary

• Symbol: Sostdc1^tm2Myan
• Name: sclerostin domain containing 1; targeted mutation 2, Motoko Yanagita
• MGI ID: MGI:4360516
• Synonyms: Sostdc1^LacZ, USAG-1^LacZ
• Gene: Sostdc1 Location: Chr12:36364168-36368451 bp, + strand Genetic Position: Chr12, 16.82 cM, cytoband B2
• Alliance: Sostdc1^tm2Myan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152884
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence was replaced with an in frame cytoplasmic lacZ gene and neo cassette via homologous recombination. In situ hybridization analysis confirmed that lacZ expression reflects endogenous gene expression. (J:152884)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sostdc1 Mutation: 28 strains or lines available

References

• Original: J:152884 Tanaka M, et al., Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Kidney Int. 2008 Jan;73(2):181-91
• All: 5 reference(s)