Tbpl2^tm1.1Lzt
Targeted Allele Detail

Summary

• Symbol: Tbpl2^tm1.1Lzt
• Name: TATA box binding protein like 2; targeted mutation 1.1, Laszlo Tora
• MGI ID: MGI:4360523
• Synonyms: Tbp2^-
• Gene: Tbpl2 Location: Chr2:23961733-23986607 bp, - strand Genetic Position: Chr2, 16.14 cM
• Alliance: Tbpl2^tm1.1Lzt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152449
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removed exon 4. The absence of protein expression was confirmed by western blot analysis on ovary extracts. (J:152449)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbpl2 Mutation: 30 strains or lines available

References

• Original: J:152449 Gazdag E, et al., TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte. Genes Dev. 2009 Sep 15;23(18):2210-23
• All: 3 reference(s)