Apc^tm2Rfo
Targeted Allele Detail

Summary

• Symbol: Apc^tm2Rfo
• Name: APC, WNT signaling pathway regulator; targeted mutation 2, Riccardo Fodde
• MGI ID: MGI:4360657
• Synonyms: Apc^1572T
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm2Rfo page

Mammary adenocarcinomas from Apc^tm2Rfo/Apc⁺ mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151494
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A hygro resistance cassette was inserted at a site corresponding to codon 1572. This mutation is predicted to result in a truncated protein. (J:151494)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm2Rfo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:151494 Gaspar C, et al., A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. PLoS Genet. 2009 Jul;5(7):e1000547
• All: 7 reference(s)