Tg(Eno2-ATN1)14Tx
Transgene Detail

Summary

• Symbol: Tg(Eno2-ATN1)14Tx
• Name: transgene insertion 14, Tian Xu
• MGI ID: MGI:4360673
• Synonyms: Atro-118Q14
• Transgene: Tg(Eno2-ATN1)14Tx Location: unknown
• Alliance: Tg(Eno2-ATN1)14Tx page

Transgene origin

• Strain of Origin: C57BL/6J x SJL/J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-ATN1)14Tx expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATN1 (1822)

  Atn1	(MGI:104725)

  The gene contains 118 CAG repeats.

• Mutation details: The transgene comprises a cDNA encoding full length human ATN1 containing a 118 residue polyglutamine tract, encoded by 118 CAG repeats, inserted into a transgenic vector containing the rat neuron-specific enolase promoter. This transgenic line carries two copies of the construct and, as shown by immunohistology and western blot analyses, expresses human ATN1 protein in the brain. (J:112706)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:112706 Ying M, et al., Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. J Biol Chem. 2006 May 5;281(18):12580-6
• All: 2 reference(s)