Tg(Eno2-ATN1)1Tx
Transgene Detail

Summary

• Symbol: Tg(Eno2-ATN1)1Tx
• Name: transgene insertion 1, Tian Xu
• MGI ID: MGI:4360674
• Synonyms: Atro-18Q
• Transgene: Tg(Eno2-ATN1)1Tx Location: unknown
• Alliance: Tg(Eno2-ATN1)1Tx page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-ATN1)1Tx expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATN1 (1822)

  Atn1	(MGI:104725)

• Mutation details: The transgene comprises a cDNA encoding full length human ATN1 containing a 18 residue polyglutamine tract, encoded by 18 CAG repeats, inserted into a transgenic vector containing the rat neuron-specific enolase promoter. This transgenic line, as shown by western blot analyses, expresses human wild type ATN1 protein in the brain. (J:112706)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:112706 Ying M, et al., Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. J Biol Chem. 2006 May 5;281(18):12580-6
• All: 2 reference(s)