Ahi1^tm1Rujf
Targeted Allele Detail

Summary

• Symbol: Ahi1^tm1Rujf
• Name: Abelson helper integration site 1; targeted mutation 1, Russell J Ferland
• MGI ID: MGI:4360696
• Gene: Ahi1 Location: Chr10:20828446-20956328 bp, + strand Genetic Position: Chr10, 9.75 cM, cytoband A3
• Alliance: Ahi1^tm1Rujf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152919
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 6 were replaced with a lacZ/neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:152919)

Expression

In Mice Carrying this Mutation:

38 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ahi1 Mutation: 80 strains or lines available

References

• Original: J:152919 Hsiao YC, et al., Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking. Hum Mol Genet. 2009 Oct 15;18(20):3926-41
• All: 9 reference(s)