Has2^tm1.1Yama
Targeted Allele Detail

Summary

• Symbol: Has2^tm1.1Yama
• Name: hyaluronan synthase 2; targeted mutation 1.1, Yu Yamaguchi
• MGI ID: MGI:4360705
• Synonyms: Has2^flox
• Gene: Has2 Location: Chr15:56529023-56557935 bp, - strand Genetic Position: Chr15, 23.31 cM
• Alliance: Has2^tm1.1Yama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152912
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 2 and a single loxP site was inserted downstream of exon 2 via homologous recombination. The neo cassette was then removed by Cre mediated recombination, leaving exon 2 floxed. (J:152912)

Expression

In Mice Carrying this Mutation:	34 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Has2 Mutation: 35 strains or lines available

References

• Original: J:152912 Matsumoto K, et al., Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb. Development. 2009 Aug;136(16):2825-35
• All: 23 reference(s)