Slc1a3^{tm2(cre/PGR*)Ksak}
Targeted Allele Detail

Summary

• Symbol: Slc1a3^{tm2(cre/PGR*)Ksak}
• Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3; targeted mutation 2, Kenji Sakimura
• MGI ID: MGI:4360731
• Synonyms: GLAST-CrePR, Slc1a3^{tm1(crePR)Ksak}, Slc1a3^{tm2(cre/PGR)Ksak}
• Gene: Slc1a3 Location: Chr15:8663608-8740248 bp, - strand Genetic Position: Chr15, 3.82 cM, cytoband A2
• Alliance: Slc1a3^{tm2(cre/PGR*)Ksak} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104881
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: mifepristone
• Mutation: Insertion
• Slc1a3^{tm2(cre/PGR*)Ksak} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc1a3 (MGI:99917)

• Mutation details: The endogenous gene's promoter drives expression of a DNA sequence encoding a fusion protein in which Cre recombinase is joined to the ligand binding domain (LBD) of the human progesterone receptor lacking the carboxyl terminal 42 amino acids. The chimeric recombinase protein is not constitutively active; its activity is inducible by binding of the mifepristone, synthetic progesterone analog RU486, to the truncated progesterone LBD. (J:104881, J:122587)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc1a3 (mouse) Summary of all recombinase alleles driven by Slc1a3. Alliance mouse Slc1a3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc1a3 Mutation: 70 strains or lines available

References

• Original: J:104881 The RIKEN BioResource Center, Information obtained from The RIKEN BioResource Center. Unpublished. 2006-2013
• All: 3 reference(s)