Dcc^tm1Nki
Targeted Allele Detail

Summary

• Symbol: Dcc^tm1Nki
• Name: DCC netrin 1 receptor; targeted mutation 1, The Netherlands Cancer Institute
• MGI ID: MGI:4360737
• Synonyms: Dcc^F
• Gene: Dcc Location: Chr18:71386705-72484140 bp, - strand Genetic Position: Chr18, 45.24 cM
• Alliance: Dcc^tm1Nki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181090
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 23 was flanked by loxP sites. The neomycin selection cassette was excised in vitro. Mutant ES cells retaining the neo cassette will not be used to create mice. (J:181090)

Expression

In Mice Carrying this Mutation:

18 assay results

Tumor Data

List all tumor models in MMHCdb carrying Dcc^tm1Nki

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dcc Mutation: 76 strains or lines available

References

• Original: J:181090 Krimpenfort P, et al., Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours. Nature. 2012 Feb 23;482(7386):538-41
• All: 20 reference(s)