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Tg(GHRL-TAg)3-1Hiwa
Transgene Detail
Summary
Symbol: Tg(GHRL-TAg)3-1Hiwa
Name: transgene insertion 3-1, Hiroshi Iwakura
MGI ID: MGI:4360904
Synonyms: GP-Tag
Transgene: Tg(GHRL-TAg)3-1Hiwa  Location: unknown  
Alliance: Tg(GHRL-TAg)3-1Hiwa page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details4.085 Kb of the human promoter was used to drive expression of the SV40 large T antigen in ghrelin-expressing cells. Three lines were established (lines 1-5, 3-1, and 4-3). (J:152492)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
adipose tissue
decreased total body fat amount
behavior/neurological
decreased food intake
digestive/alimentary system
gastric hypertrophy
increased stomach tumor incidence
growth/size/body
decreased body weight
homeostasis/metabolism
increased circulating glucose level
decreased circulating insulin level
increased circulating insulin-like growth factor I level
decreased circulating leptin level
impaired glucose tolerance
neoplasm
increased stomach tumor incidence
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: Ghrelinoma (J:152492)
References
Original:  J:152492 Iwakura H, et al., A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance. Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E802-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory