Tg(GHRL-TAg)3-1Hiwa
Transgene Detail
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Symbol: |
Tg(GHRL-TAg)3-1Hiwa |
Name: |
transgene insertion 3-1, Hiroshi Iwakura |
MGI ID: |
MGI:4360904 |
Synonyms: |
GP-Tag |
Transgene: |
Tg(GHRL-TAg)3-1Hiwa Location: unknown
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Alliance: |
Tg(GHRL-TAg)3-1Hiwa page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Mutation details: 4.085 Kb of the human promoter was used to drive expression of the SV40 large T antigen in ghrelin-expressing cells. Three lines were established (lines 1-5, 3-1, and 4-3).
(J:152492)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Phenotypes: |
Affected Systems |
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adipose tissue
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decreased total body fat amount
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behavior/neurological
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decreased food intake
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digestive/alimentary system
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gastric hypertrophy
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increased stomach tumor incidence
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growth/size/body
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decreased body weight
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homeostasis/metabolism
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increased circulating glucose level
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decreased circulating insulin level
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increased circulating insulin-like growth factor I level
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decreased circulating leptin level
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impaired glucose tolerance
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neoplasm
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increased stomach tumor incidence
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Phenotypic Similarity to Human Syndrome: Ghrelinoma (J:152492)
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Original: |
J:152492 Iwakura H, et al., A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance. Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E802-11 |
All: |
1 reference(s) |
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