Nfil3^tm1.1Brad
Targeted Allele Detail

Summary

• Symbol: Nfil3^tm1.1Brad
• Name: nuclear factor, interleukin 3, regulated; targeted mutation 1.1, Hugh Brady
• MGI ID: MGI:4360908
• Synonyms: E4bp4^-
• Gene: Nfil3 Location: Chr13:53121245-53135109 bp, - strand Genetic Position: Chr13, 27.68 cM
• Alliance: Nfil3^tm1.1Brad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152774
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the coding region and a floxed neo cassette was inserted downstream of the coding exon. Germ line, cre mediated recombination removes the neo cassette and coding exon. The absence of protein expression was confirmed by western blot analysis on heart extracts. (J:152774)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfil3 Mutation: 32 strains or lines available

References

• Original: J:152774 Gascoyne DM, et al., The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development. Nat Immunol. 2009 Oct;10(10):1118-24
• All: 17 reference(s)