Tg(Trp53)1Srn
Transgene Detail

Summary

• Symbol: Tg(Trp53)1Srn
• Name: transgene insertion 1, Manuel Serrano
• MGI ID: MGI:4360913
• Synonyms: p53-tg, super p53
• Transgene: Tg(Trp53)1Srn Location: unknown
• Alliance: Tg(Trp53)1Srn page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Trp53)1Srn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trp53 (MGI:98834)

• Mutation details: Bacterial artificial chromosome (BAC) library was used to obtain a 130 kb BAC containing the entire mouse Trp53 (transformation related protein 53) gene in it's "natural genomic context". Trp53 is located at the terminal end of the segment. The other end of the BAC falls in the middle of the Dnahc2 gene. This line carries one copy of the transgene.

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Trp53)1Srn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:80311 Garcia-Cao I, et al., 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 2002 Nov 15;21(22):6225-35
• All: 16 reference(s)