Wnk1^tm1Clhu
Targeted Allele Detail

Summary

• Symbol: Wnk1^tm1Clhu
• Name: WNK lysine deficient protein kinase 1; targeted mutation 1, Chou-Long Huang
• MGI ID: MGI:4360972
• Synonyms: Wnk1^flox
• Gene: Wnk1 Location: Chr6:119900930-120015633 bp, - strand Genetic Position: Chr6, 56.86 cM
• Alliance: Wnk1^tm1Clhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152906
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a neo cassette and second loxP site were inserted downstream of exon 2. (J:152906)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnk1 Mutation: 115 strains or lines available

References

• Original: J:152906 Xie J, et al., Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol. 2009 Sep;175(3):1315-27
• All: 9 reference(s)