Tg(MMTV-Erbb2*,-cre)1Mul
Transgene Detail

Summary

• Symbol: Tg(MMTV-Erbb2*,-cre)1Mul
• Name: transgene insertion 1, William J Muller
• MGI ID: MGI:4361017
• Synonyms: MMTV-Neu-IRES-CRE, MMTV-NeuNDL2-5-IRES-Cre, MMTV-NIC, NIC
• Transgene: Tg(MMTV-Erbb2*,-cre)1Mul Location: unknown
• Alliance: Tg(MMTV-Erbb2*,-cre)1Mul page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Recombinase)
• Mutation: Insertion
• Tg(MMTV-Erbb2*,-cre)1Mul expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Erbb2 (MGI:95410)

• Tg(MMTV-Erbb2*,-cre)1Mul expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  virus	MMTV

• Mutation details: A transgene was generated where an activated Erbb2 (Neu, oncogenic form NDL2-5) and cre recombinase (coupled by an internal ribosomal entry site (IRES)) are under control of the mammalian mammary tumor virus promoter (MMTV). (J:133325)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	MMTV (virus) Summary of all recombinase alleles driven by MMTV.

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-Erbb2*,-cre)1Mul

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:133325 Ursini-Siegel J, et al., ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J. 2008 Mar 19;27(6):910-20
• All: 39 reference(s)