Cxcr3^tm1Raks
Targeted Allele Detail

Summary

• Symbol: Cxcr3^tm1Raks
• Name: C-X-C motif chemokine receptor 3; targeted mutation 1, Rolf A K Stahl
• MGI ID: MGI:4361116
• Gene: Cxcr3 Location: ChrX:100775141-100777753 bp, - strand Genetic Position: ChrX, 44.58 cM
• Alliance: Cxcr3^tm1Raks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153194
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 was replaced with a neo cassette. Flow cytometry confirmed the absence of CD3+ T cells expressing the protein. (J:153194)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcr3 Mutation: 14 strains or lines available

References

• Original: J:153194 Panzer U, et al., Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice. J Am Soc Nephrol. 2007 Jul;18(7):2071-84
• All: 8 reference(s)