Hunk^tm1Lach
Targeted Allele Detail

Summary

• Symbol: Hunk^tm1Lach
• Name: hormonally upregulated Neu-associated kinase; targeted mutation 1, Lewis A Chodosh
• MGI ID: MGI:4361146
• Gene: Hunk Location: Chr16:90182901-90296441 bp, + strand Genetic Position: Chr16, 51.71 cM
• Alliance: Hunk^tm1Lach page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153075
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 1.1 kb genomic fragment including the putative promoter and exon 1 was replaced with a floxed pgk-neo cassette via homologous recombination. (J:153075)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hunk Mutation: 44 strains or lines available

References

• Original: J:153075 Wertheim GB, et al., The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15855-60
• All: 3 reference(s)