Wnt2^{tm1.1(rtTA)Eem}
Targeted Allele Detail

Summary

• Symbol: Wnt2^{tm1.1(rtTA)Eem}
• Name: wingless-type MMTV integration site family, member 2; targeted mutation 1.1, Edward E Morrisey
• MGI ID: MGI:4361155
• Synonyms: Wnt2^-
• Gene: Wnt2 Location: Chr6:17988939-18030584 bp, - strand Genetic Position: Chr6, 8.08 cM, cytoband A2-A3.1
• Alliance: Wnt2^{tm1.1(rtTA)Eem} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153098
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region in exon 1 was replaced with a reverse tet-activator (rtTA). A downstream FRT flanked neo cassette was removed by germ line, flp mediated recombination. (J:153098)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt2 Mutation: 26 strains or lines available

References

• Original: J:153098 Goss AM, et al., Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell. 2009 Aug;17(2):290-8
• All: 2 reference(s)