Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko
Transgene Detail

Summary

• Symbol: Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko
• Name: transgene insertion 8, Makoto Mark Taketo
• MGI ID: MGI:4361186
• Synonyms: K19-C2mE, K19-C2mE8
• Transgene: Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko Location: unknown
• Alliance: Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko page

Transgene origin

• Strain of Origin: (C3H x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptges (MGI:1927593)
  mouse	Ptgs2 (MGI:97798)

• Mutation details: The mouse promoter drives expression of the two mouse cDNAs in the epithelial cells of gastric mucosa. Two lines were created (lines 2 and 8) with similar phenotypes. Line 8 was selected as the representative line. (J:88759)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88759 Oshima H, et al., Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice. EMBO J. 2004 Apr 7;23(7):1669-78
• All: 17 reference(s)