Nfil3^tm1Look
Targeted Allele Detail

Summary

• Symbol: Nfil3^tm1Look
• Name: nuclear factor, interleukin 3, regulated; targeted mutation 1, A Thomas Look
• MGI ID: MGI:4361260
• Synonyms: Nfil3^-
• Gene: Nfil3 Location: Chr13:53121245-53135109 bp, - strand Genetic Position: Chr13, 27.68 cM
• Alliance: Nfil3^tm1Look page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153064
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A 2.2 kb fragment including exon 2 was replaced with a neomycin cassette by homologous recombination. The absence of transcript expression was confirmed by RT-PCR on hepatic extracts. (J:153064, J:155677)

Generation of the Nfil3^tm1Look allele

Tumor Data

List all tumor models in MMHCdb carrying Nfil3^tm1Look

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfil3 Mutation: 32 strains or lines available

References

• Original: J:153064 Le Martelot G, et al., REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol. 2009 Sep;7(9):e1000181
• All: 22 reference(s)