Tbx22^tm1Sta
Targeted Allele Detail

Summary

• Symbol: Tbx22^tm1Sta
• Name: T-box 22; targeted mutation 1, Philip Stanier
• MGI ID: MGI:4361266
• Synonyms: Tbx22^flox, Tbx22^{tm1(flox/exon0-2/NEO)Sta}
• Gene: Tbx22 Location: ChrX:106711570-106732584 bp, + strand Genetic Position: ChrX, 47.59 cM
• Alliance: Tbx22^tm1Sta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153100
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites to flank the first three exons, including the start codon, the N-terminal repression domain, nuclear localization signal and part of the T-box domain. In addition, an frt flanked neomycin resistance cassette was inserted into the intron after the third exon. (J:153100)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tbx22 Mutation: 5 strains or lines available

References

• Original: J:153100 Pauws E, et al., Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes. Hum Mol Genet. 2009 Nov 1;18(21):4171-9
• All: 1 reference(s)