Tbx22^tm1.1Sta
Targeted Allele Detail

Summary

• Symbol: Tbx22^tm1.1Sta
• Name: T-box 22; targeted mutation 1.1, Philip Stanier
• MGI ID: MGI:4361267
• Synonyms: Tbx22^null, Tbx22^{tm1.1(b-actin/Dexon0-2/NEO)Sta}
• Gene: Tbx22 Location: ChrX:106711570-106732584 bp, + strand Genetic Position: ChrX, 47.59 cM
• Alliance: Tbx22^tm1.1Sta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153100
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first three exons, including the start codon, the N-terminal repression domain, nuclear localization signal and part of the T-box domain was deleted upon cre mediated recombination. A neomycin resistance cassette was inserted in the intron after the third exon. (J:153100)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx22 Mutation: 5 strains or lines available

References

• Original: J:153100 Pauws E, et al., Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes. Hum Mol Genet. 2009 Nov 1;18(21):4171-9
• All: 1 reference(s)