Hoxd13^Dyc
Spontaneous Allele Detail

Summary

• Symbol: Hoxd13^Dyc
• Name: homeobox D13; digit in Y-shaped finger and carpe
• MGI ID: MGI:4361275
• Gene: Hoxd13 Location: Chr2:74498654-74501943 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Hoxd13^Dyc page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Spontaneous
• Mutations: Duplication, Nucleotide repeat expansion
• Mutation details: Spontaneous duplications, likely due to fork stalling and template switching, expand the polyalanine stretch in exon 1 from 15 to 22 alanines. (J:153164)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hoxd13 Mutation: 24 strains or lines available

References

• Original: J:153164 Cocquempot O, et al., Fork stalling and template switching as a mechanism for polyalanine tract expansion affecting the DYC mutant of HOXD13, a new murine model of synpolydactyly. Genetics. 2009 Sep;183(1):23-30
• All: 1 reference(s)