Slc2a9^tm1.1Thor
Targeted Allele Detail

Summary

• Symbol: Slc2a9^tm1.1Thor
• Name: solute carrier family 2 (facilitated glucose transporter), member 9; targeted mutation 1.1, Bernard Thorens
• MGI ID: MGI:4361276
• Synonyms: Glut9^lox
• Gene: Slc2a9 Location: Chr5:38506616-38660486 bp, - strand Genetic Position: Chr5, 20.43 cM
• Alliance: Slc2a9^tm1.1Thor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153089
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and an frt flanked neo cassette were inserted upstream of exon 4 and a second loxP site was inserted downstream of exon 4. Flp mediated recombination then removed the neo cassette leaving exon 4 floxed. (J:153089)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Slc2a9 Mutation: 42 strains or lines available

References

• Original: J:153089 Preitner F, et al., Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15501-6
• All: 7 reference(s)