Myo15a^{tm1.1(cre)Ugds}
Targeted Allele Detail

Summary

• Symbol: Myo15a^{tm1.1(cre)Ugds}
• Name: myosin XVA; targeted mutation 1.1, Unite de Genetique des Deficits Sensoriels
• MGI ID: MGI:4361284
• Synonyms: Myo15-cre
• Gene: Myo15a Location: Chr11:60360165-60419195 bp, + strand Genetic Position: Chr11, 37.81 cM
• Alliance: Myo15a^{tm1.1(cre)Ugds} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171218
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Myo15a^{tm1.1(cre)Ugds} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myo15a (MGI:1261811)

• Mutation details: A cre gene and FRT flanked hygromycin cassette were inserted at the transcriptional start site. Flp mediated recombination removed the hygromycin cassette. (J:171218)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myo15a (mouse) Summary of all recombinase alleles driven by Myo15a. Alliance mouse Myo15a gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo15a Mutation: 136 strains or lines available

References

• Original: J:171218 Caberlotto E, et al., Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5825-30
• All: 12 reference(s)