Grin1^tm1.1Ese
Targeted Allele Detail

Summary

• Symbol: Grin1^tm1.1Ese
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1.1, Effat S Emamian
• MGI ID: MGI:4361333
• Synonyms: NR1 S897A
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm1.1Ese page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153043
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitution results in the amino acid substitution of alanine for serine at position 897 (S897A). An frt flanked neo cassette was removed by transient flp expression in ES cells. (J:153043)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 67 strains or lines available

References

• Original: J:153043 Li B, et al., NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity. J Neurosci. 2009 Sep 23;29(38):11965-72
• All: 2 reference(s)