Map3k4^byg
Chemically induced Allele Detail

Summary

• Symbol: Map3k4^byg
• Name: mitogen-activated protein kinase kinase kinase 4; boygirl
• MGI ID: MGI:4361339
• Synonyms: byg, RECB/31
• Gene: Map3k4 Location: Chr17:12446508-12537683 bp, - strand Genetic Position: Chr17, 8.42 cM
• Alliance: Map3k4^byg page

Exencephaly, spina bifida, mild edema, and gonadal abnormalities with XY gonadal sex reversal in Map3k4^byg/Map3k4^byg embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis induced a nucleotide substitution that results in the amino acid substitution of arginine with a premature stop codon at position 382 of 1597 (R382X). Absence of the full length protein expression as confirmed by western blot analysis. (J:153050)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map3k4 Mutation: 78 strains or lines available

References

• Original: J:153050 Bogani D, et al., Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol. 2009 Sep;7(9):e1000196
• All: 1 reference(s)