Ush1g^tm1.1Ugds
Targeted Allele Detail

Summary

• Symbol: Ush1g^tm1.1Ugds
• Name: USH1 protein network component sans; targeted mutation 1.1, Unite de Genetique des Deficits Sensoriels
• MGI ID: MGI:4361359
• Synonyms: Ush1g^fl
• Gene: Ush1g Location: Chr11:115206018-115212867 bp, - strand Genetic Position: Chr11, 80.84 cM
• Alliance: Ush1g^tm1.1Ugds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171218
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:171218)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ush1g Mutation: 16 strains or lines available

References

• Original: J:171218 Caberlotto E, et al., Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5825-30
• All: 1 reference(s)