Ifngr1^tm1.1Rost
Targeted Allele Detail

Summary

• Symbol: Ifngr1^tm1.1Rost
• Name: interferon gamma receptor 1; targeted mutation 1.1, Robyn Starr
• MGI ID: MGI:4361521
• Synonyms: Ifngr1^441F
• Gene: Ifngr1 Location: Chr10:19467697-19485977 bp, + strand Genetic Position: Chr10, 8.49 cM
• Alliance: Ifngr1^tm1.1Rost page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152785
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 7 contains a nucleotide substitution (TAT -> TTT) that results in the amino acid substitution of tyrosine with phenylalanine at position 441 (Y441F). A downstream floxed neo was removed by germ line, cre mediated recombination. The mutated amino acid is within the Socs1 binding site. (J:152785)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ifngr1 Mutation: 53 strains or lines available

References

• Original: J:152785 Starr R, et al., SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo. J Immunol. 2009 Oct 1;183(7):4537-44
• All: 1 reference(s)