Crtam^tm1Tks
Targeted Allele Detail

Summary

• Symbol: Crtam^tm1Tks
• Name: cytotoxic and regulatory T cell molecule; targeted mutation 1, Takashi Saito
• MGI ID: MGI:4361562
• Synonyms: CRTAM^-
• Gene: Crtam Location: Chr9:40880987-40915922 bp, - strand Genetic Position: Chr9, 21.79 cM
• Alliance: Crtam^tm1Tks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152770
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette flanked by loxP sites replaced exon 1 of the gene locus, deleting the ATG start site. No protein was detected in CD8+ splenic T cells by flow cytometry assays. (J:152770)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crtam Mutation: 21 strains or lines available

References

• Original: J:152770 Takeuchi A, et al., CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node. J Immunol. 2009 Oct 1;183(7):4220-8
• All: 2 reference(s)