Slc30a8^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Slc30a8^tm1.1Geno
• Name: solute carrier family 30 (zinc transporter), member 8; targeted mutation 1.1, Genoway
• MGI ID: MGI:4362061
• Synonyms: ZnT8^-
• Gene: Slc30a8 Location: Chr15:52158949-52199194 bp, + strand Genetic Position: Chr15, 19.88 cM
• Alliance: Slc30a8^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153253
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removed exon 1 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on pancreatic extracts. (J:153253)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc30a8 Mutation: 23 strains or lines available

References

• Original: J:153253 Lemaire K, et al., Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14872-7
• All: 8 reference(s)