Gpt2tm1a(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Gpt2tm1a(KOMP)Wtsi |
Name: |
glutamic pyruvate transaminase (alanine aminotransferase) 2; targeted mutation 1a, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:4363039 |
Gene: |
Gpt2 Location: Chr8:86219205-86254189 bp, + strand Genetic Position: Chr8, 41.61 cM, cytoband C2
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Alliance: |
Gpt2tm1a(KOMP)Wtsi page
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IMPC: |
Gpt2 gene page |
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Reduction in brain size in Gpt2tm1a(KOMP)Wtsi/Gpt2tm1a(KOMP)Wtsi mice
Show the 1 phenotype image(s) involving this allele.
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Mutant Cell Lines: |
EPD0041_2_B06, EPD0041_2_C04, EPD0041_2_F06, EPD0041_2_H06, EPD0067_1_A02, EPD0067_1_B01, EPD0067_1_B02, EPD0067_1_B03, EPD0067_1_C02, EPD0067_1_C03, EPD0067_1_D01, EPD0067_1_D02, EPD0067_1_E02, EPD0067_1_F02, EPD0067_1_G01, EPD0067_1_G03, EPD0067_1_H01, EPD0067_1_H02 |
Germline Transmission: |
Earliest citation of germline transmission:
J:238353
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Parent Cell Line: |
JM8.F6 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready, Null/knockout, Reporter) |
Mutation: |
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Insertion
Vector: L1L2_gt0
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Mutation details: The L1L2_gt0 cassette was inserted at position 86231739 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 86232560. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:148605, J:173534, J:238353)
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Generation of the Gpt2tm1a(KOMP)Wtsi allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009; |
All: |
9 reference(s) |
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