Fads2^tm1Mtna
Targeted Allele Detail

Summary

• Symbol: Fads2^tm1Mtna
• Name: fatty acid desaturase 2; targeted mutation 1, Manabu T Nakamura
• MGI ID: MGI:4365366
• Synonyms: Fads2-
• Gene: Fads2 Location: Chr19:10040129-10078867 bp, - strand Genetic Position: Chr19, 6.36 cM, cytoband B
• Alliance: Fads2^tm1Mtna page

Female Fads2^tm1Mtna/Fads2^tm1Mtna mice exhibit dermatitis, enlarged spleen and liver, and intestinal ulcer when fed a diet lacking delta-6 desaturase products

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153293
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Exon 1 was replaced with a neo cassette. The absence of transcript expression was confirmed. (J:153293)

Generation of the Fads2^tm1Mtna allele

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fads2 Mutation: 21 strains or lines available

References

• Original: J:153293 Stroud CK, et al., Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration. J Lipid Res. 2009 Apr 7;50:1871-1880
• All: 8 reference(s)