Cdsn^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Cdsn^tm1.1Ics
• Name: corneodesmosin; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:4365388
• Synonyms: Cdsn^fl
• Gene: Cdsn Location: Chr17:35863025-35868077 bp, + strand Genetic Position: Chr17, 18.7 cM
• Alliance: Cdsn^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153292
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a second loxP site and frt flanked neo cassette were inserted downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:153292)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdsn Mutation: 21 strains or lines available

References

• Original: J:153292 Leclerc EA, et al., Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction. J Cell Sci. 2009 Aug 1;122(Pt 15):2699-709
• All: 3 reference(s)