Mmp24^tm1Otin
Targeted Allele Detail

Summary

• Symbol: Mmp24^tm1Otin
• Name: matrix metallopeptidase 24; targeted mutation 1, Carlos Lopez-Otin
• MGI ID: MGI:4365393
• Gene: Mmp24 Location: Chr2:155617262-155660286 bp, + strand Genetic Position: Chr2, 77.26 cM
• Alliance: Mmp24^tm1Otin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153230
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 and 6 were replaced with a neo cassette. Northern blot analysis confirmed the expression of a truncated transcript lacking enzymatic domains in the cerebellum. (J:153230)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp24 Mutation: 32 strains or lines available

References

• Original: J:153230 Folgueras AR, et al., Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16451-6
• All: 2 reference(s)