Nppc^tm1.1Fgr
Targeted Allele Detail

Summary

• Symbol: Nppc^tm1.1Fgr
• Name: natriuretic peptide type C; targeted mutation 1.1, Fritz G Rathjen
• MGI ID: MGI:4365461
• Synonyms: CNPlacZ^-, Nppc^lacZ
• Gene: Nppc Location: Chr1:86594015-86598295 bp, - strand Genetic Position: Chr1, 43.98 cM
• Alliance: Nppc^tm1.1Fgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153212
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a lacZ with a nuclear localization signal and a floxed cre-neo cassette, which excises itself. Exon 2 was also modified to introduce STOP codons in all three frames. The absence of protein expression as confirmed by immunohistochemistry on E12.5 spinal cord sections. (J:153212)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nppc Mutation: 12 strains or lines available

References

• Original: J:153212 Schmidt H, et al., C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16847-52
• All: 3 reference(s)