Ptpn11^tm1.1Wbm
Targeted Allele Detail

Summary

• Symbol: Ptpn11^tm1.1Wbm
• Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1.1, Walter Birchmeier
• MGI ID: MGI:4365539
• Synonyms: Ptpn11^tm1.1Cbm, Shp2^fl
• Gene: Ptpn11 Location: Chr5:121268596-121329460 bp, - strand Genetic Position: Chr5, 61.72 cM, cytoband F
• Alliance: Ptpn11^tm1.1Wbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153219
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. The neo cassette was removed by germ line, flp mediated recombination. (J:153219)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn11 Mutation: 46 strains or lines available

References

• Original: J:153219 Grossmann KS, et al., The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16704-9
• All: 11 reference(s)