Trim21^tm1Mwah
Targeted Allele Detail

Summary

• Symbol: Trim21^tm1Mwah
• Name: tripartite motif-containing 21; targeted mutation 1, Marie Wahren-Herlenius
• MGI ID: MGI:4365543
• Synonyms: Ro52^-
• Gene: Trim21 Location: Chr7:102207127-102214689 bp, - strand Genetic Position: Chr7, 54.76 cM, cytoband F1
• Alliance: Trim21^tm1Mwah page

Tissue inflammation of ears of tagged Trim21^tm1MwahTrim21^tm1Mwah mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151775
• Parent Cell Line: V26.2 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion IRES-GFP reporter cassette and loxP flanked neo cassette replaced Exons 5-8 of the gene. (J:151775)

Generation of the Trim21^tm1Mwah allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim21 Mutation: 26 strains or lines available

References

• Original: J:151775 Espinosa A, et al., Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J Exp Med. 2009 Aug 3;206(8):1661-71
• All: 3 reference(s)