Trp73^tm1(cre)Agof
Targeted Allele Detail

Summary

• Symbol: Trp73^tm1(cre)Agof
• Name: transformation related protein 73; targeted mutation 1, Andre M Goffinet
• MGI ID: MGI:4365581
• Synonyms: DeltaNp73^-, DeltaNp73-Cre, DeltaNp73^CreiresEGFP
• Gene: Trp73 Location: Chr4:154140706-154224332 bp, - strand Genetic Position: Chr4, 83.79 cM
• Alliance: Trp73^tm1(cre)Agof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153209
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Trp73^tm1(cre)Agof expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Trp73 (MGI:1336991)

• Mutation details: A cre recombinase sequence was targeted to the Trp73 locus in frame at the alternative start codon located in exon 3' (where transcription of the DeltaNp73 isoform is initiated), inactivating the DeltaNp73 isoform and leaving the primary Trp73 transcript (TAp73) unaffected. The cre sequence is followed by an internal ribosomal entry site (IRES) and an EGFP coding sequence. The targeting construct that was used also contains an FRT-flanked Neo cassette and a diphtheria toxin A (DTA) negative selection cassette. (J:153209)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Trp73 (mouse) Summary of all recombinase alleles driven by Trp73. Alliance mouse Trp73 gene page

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp73 Mutation: 46 strains or lines available

References

• Original: J:153209 Tissir F, et al., DeltaNp73 regulates neuronal survival in vivo. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16871-6
• All: 16 reference(s)