Hoxc8^{tm4(Hoxc9)Jepl}
Targeted Allele Detail

Summary

• Symbol: Hoxc8^{tm4(Hoxc9)Jepl}
• Name: homeobox C8; targeted mutation 4, Jeh-Ping Liu
• MGI ID: MGI:4365798
• Synonyms: Hoxc8-c9^F-LacZ
• Gene: Hoxc8 Location: Chr15:102899039-102902543 bp, + strand Genetic Position: Chr15, 58.05 cM
• Alliance: Hoxc8^{tm4(Hoxc9)Jepl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153560
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted into exon 1 upstream of the initiation codon and a cassette containing a 5' loxP site, the Hoxc9 coding region, intron 2 sequence with flanking splice acceptor and donor sites, an IRES, a nuclear localized LacZ gene, an additional copy of the 3'UTR, and a neo resistance gene was inserted downstream of the 3'UTR. (J:153560)

Generation of the Hoxc8^tm3(Hoxc9)Jepl and Hoxc8^tm4(Hoxc9)Jepl alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxc8 Mutation: 8 strains or lines available

References

• Original: J:153560 Blackburn J, et al., Generation of conditional Hoxc8 loss-of-function and Hoxc8-->Hoxc9 replacement alleles in mice. Genesis. 2009 Jul 20;47(10):680-687
• All: 1 reference(s)